Titelbild: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. 10/2022)
نویسندگان
چکیده
Die T-Zelltherapie mit chimären Antigenrezeptoren (CAR) leidet unter Komplikationen wie Zytokinfreisetzungssyndromen und T-Zell-Erschöpfung. Um diesen Nachteilen entgegenzuwirken, berichten Jianfeng Zhou, Wenshe Ray Liu et al. in ihrem Forschungsartikel (e202109550) über einen chemogenetischen Schalter, der reversibel ein- ausgeschaltet werden kann, um die CAR-Expression mithilfe eines klinisch zugelassenen niedermolekularen Medikaments, Asunaprevir, zu steuern. Diese neuartige Technik könnte eine fein abgestimmte Modulation CAR-T-Aktivierung während Krebsbehandlung ermöglichen. Elektronentransfer Batterien Dendrimere Nanographen
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2022
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202201860